Visible light amination/Smiles cascade: access to phthalazine derivatives
نویسندگان
چکیده
Université Sorbonne Paris Cité (USPC), Pharmacie de Paris, UMR CNRS 8638 (COM Paris, France. E-mail: etienne.brachet parisdescartes.fr University of Regensburg Faculty of Chem Chemistry, Universitätsstraße 31, 93053 Re Université Sorbonne Paris Cité (USPC), Pharmacie de Paris, UMR CNRS 8015 (LC Paris, France † Electronic supplementary information ( and crystallographic data in CIF or 10.1039/c6sc01095d Cite this: DOI: 10.1039/c6sc01095d
منابع مشابه
N-Acyloxyphthalimides as Nitrogen Radical Precursors in the Visible Light Photocatalyzed Room Temperature C–H Amination of Arenes and Heteroarenes
This paper reports a room temperature visible light photocatalyzed method for the C-H amination of arenes and heteroarenes. A key enabling advance in this work is the design of N-acyloxyphthalimides as precursors to nitrogen-based radical intermediates for these transformations. A broad substrate scope is presented, including the selective meta-amination of pyridine derivatives. A radical aroma...
متن کاملTeaching Old Compounds New Tricks: DDQ‐Photocatalyzed C−H Amination of Arenes with Carbamates, Urea, and N‐Heterocycles
The C-H amination of benzene derivatives was achieved using DDQ as photocatalyst and BocNH2 as the amine source under aerobic conditions and visible light irradiation. Electron-deficient and electron-rich benzenes react as substrates with moderate to good product yields. The amine scope of the reaction comprises Boc-amine, carbamates, pyrazoles, sulfonimides and urea. Preliminary mechanistic in...
متن کاملHighly efficient synthesis of tetrahydrobenzo[b]pyrans under visible light promoted by cesium carbonate
Multi-component coupling reaction (MCR) is a powerful synthetic tool for the synthesis of biologically active compounds. Development of such multi-component coupling reaction strategies in visible light has been of considerable interest, as they provide simple and rapid access to a large number of organic molecules through a sustainable path. An efficient and green protocol for the synthesis of...
متن کاملA Brief Review on Pharmacological Effect of Some Phthalazine Derivatives on Cardiovascular and Kidney Functions
Phthalazine derivatives are biological potential compounds having diverse biological activities. In this review, briefly discuss about the effect of phthalazine derivatives on cardiac and kidney functions. A series of 4-(4-bromophenyl) phthalazine and phthalazinone analogs connected through 2-propanol spacer to N-substituted piperazine residue were tested for their effect on β-adrenergic blocki...
متن کاملA simple, solvent-free four-component domino synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives catalyzed by copper (II) oxide
An eco-safe and facile multi-component domino reaction has been described for the synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives. The products were obtained by a four-component condensation reaction between phthalimide, hydrazine monohydrate, aromatic aldehyde derivatives and malononitrile in the presence of a catalytic amount of copper (II) oxide (CuO) ...
متن کامل